Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding
نویسندگان
چکیده
منابع مشابه
Identification and analysis of prophet of Pit-1-binding sites in human Pit-1 gene.
Prophet of Pit-1 (Prop1) is a transcription factor that regulates Pit-1 gene expression. Because Pit-1 regulates the differentiation of pituitary cells and the expressions of GH, prolactin and TSHbeta genes, Prop1 mutation results in combined pituitary hormone deficiency in humans. However, Prop1-binding sites in human Pit-1 gene and the mechanism leading to combined pituitary hormone deficienc...
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متن کاملA single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions.
Activation of the human growth hormone (hGH-N) gene in pituitary somatotropes is mediated by a locus control region (LCR). This LCR is composed of DNase I-hypersensitive sites (HS) located -14.5 kb to -32 kb relative to the hGH-N promoter. HSI, at -14.5 kb, is the dominant determinant of hGH-N expression and is essential for establishment of a 32-kb domain of histone acetylation that encompasse...
متن کاملCloning of the human cDNA for transcription factor Pit-1.
The mammalian pit-1 gene encodes a 33 kd transcription factor (1,2) expressed in a subset of endocrine cells of the anterior pituitary (3). Pit-1 is structurally related to the POU family of transcriptional regulators (4), containing a characteristic POU domain divided into two regions, the POU-specific and homeo subdomains. Located in the C-terminal half of the protein, the POU domain is criti...
متن کاملRibozymes acting against the transcription factor Pit-1.
Ribozymes are a group of RNA molecules which possess the catalytic activity to cleave and/or ligate RNA molecules. They are found in such diverse situations as group I and I1 introns, virusoid genomes and satellite RNAs of a number of viruses. Most characterised ribozymes perform intramolecular catalysis but a few carry out intermolecular catalysis. The ribozymes described here follow the model...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.192693499